BIO4102 Immunopathology 1

BIO	4102	75139	1, 2008	ONC	Immunopathology 1	1.00	Toowoomba
Subject	Cat-nbr	Class	Term	Mode	Description	Units	Campus

Academic group:	FOSCI
Academic org:	FOS002
Student contribution band:	2
ASCED code:	010913

Staffing
Requisites
Rationale
Synopsis
Objectives
Topics
Texts
Reference materials
Student workload
Assessment details
Important assessment information
Production date
PDF version

STAFFING

Examiner: Michael Kotiw
Moderator: John Dearnaley

REQUISITES

Pre-requisite: BIO2205 or equivalent

RATIONALE

This is a theory only course of study. The course aims to provide a thorough understanding of the principles of human immunology with particular emphasis on host response to microbial infection. The course particularly aims to provide an understanding of immunological processes associated with the ability to distinguish self from non-self antigens, immunochemistry, immunobiology, abnormal immune responses including autoimmunity and allergies/hypersensitivities. The course also aims to provide an understanding of the pathogenic processes associated with a range of infectious agents with an emphasis on viruses infecting humans. The course also aims to provide training and experience in research methodology so as to provide a platform for candidates wishing to undertake studies for higher degrees by research.

SYNOPSIS

This course provides the principles underpinning humoral or cellular defence mechanisms associated with the host response to infection. The course includes a study of innate defence mechanisms, antigenic specificity, induction of humoral and cellular immune responses, immunoglobulin structure, function and genetic basis of antibody diversity, the role of the immune system in health and disease including cell-mediated immunity, hypersensitivity reactions, autoimmunity, immune tolerance, and vaccine development strategies. The course also leads students to understand the mechanisms of microbial pathogenesis with specific emphasis on viral diseases affecting humans. The course provides candidates with a perspective of the diversity associated with medical microbiology investigations and provides students with career choices for their future. Candidates will undertake research methods training by completing an Investigative Research report.

OBJECTIVES

On completion of this course students will be able to:

1.: demonstrate an awareness of the diversity of medically important infectious diseases (Closed Exam);
2.: demonstrate an understanding of the nature of an integrated human immune system including aspects of the innate, humoral and cell mediated immune responses to infectious agents (Closed Exam);
3.: describe the different classes/subclasses of immunoglobulins/antibodies, their structure and function (Closed Exam);
4.: demonstrate an understanding of the concept of antibody specificity (Closed Exam);
5.: describe the role played by the innate defence mechanisms including inflammatory responses, the complement system and its function, antiphagocytic mechanisms and the role played by cytokines in protection against infectious disease (Closed Exam);
6.: describe the nature of autoimmune diseases and hypersensitivity (Closed Exam);
7.: describe concepts in vaccine development (Closed Exam);
8.: describe the biology and pathogenic mechanisms associated with major viral pathogens affecting humans (Closed Exam);
9.: undertake research methods training by completing an Investigative Research report (Investigative Report).

TOPICS

	Description	Weighting (%)
1.	Overview of medical microbiology	4.00
2.	Overview of the human immune system	8.00
3.	Immunogens and antigens	8.00
4.	Antibody structure and function	8.00
5.	B lymphocytes biology, activation and function	8.00
6.	T lymphocytes biology, activation and function	8.00
7.	Major histocompatibility complexes	8.00
8.	Cytokines	8.00
9.	Complement	4.00
10.	Autoimmune diseases and hypersensitivity	4.00
11.	Vaccinology	8.00
12.	Virology	16.00
13.	Mycosis	4.00
14.	Parasitology	4.00

TEXT and MATERIALS required to be PURCHASED or accessed

ALL textbooks and materials are available for purchase from USQ BOOKSHOP (unless otherwise stated). Orders may be placed via secure internet, free fax 1800642453, phone 07 46312742 (within Australia), or mail. Overseas students should fax +61 7 46311743, or phone +61 7 46312742. For costs, further details, and internet ordering, use the 'Textbook Search' facility at http://bookshop.usq.edu.au click 'Semester', then enter your 'Course Code' (no spaces).

Coico, R, Sunshine, G & Benjamini, E 2003, Immunology: a short course, 5th edn, Wiley-Liss, Davis, Calif.

REFERENCE MATERIALS

Reference materials are materials that, if accessed by students, may improve their knowledge and understanding of the material in the course and enrich their learning experience.

Alberts, B et al 2002, Molecular biology of the cell, 4th edn, Garland Science, Davis, Calif.

Goldsby, RA, Kindt, TJ & Osborne, BA 2003, Kuby immunology, 5th edn, WH Freeman & Co.

Janeway, CA et al 2005, Immunology, 6th edn, Churchill Livingstone, New York.

Mandell, GL et al 2005, Principles and practice of infectious diseases, 6th edn, PA Elsevier Churchill Livingstone, Philadelphia, vol 1&2.

Murray, PR et al 2005, Medical microbiology, 5th edn, Mosby, St Louis.

Roitt, I, Brostoff, J & Male, D 2006, Immunology, 7th edn, Mosby, London.

Salyers, AA & Whitt, DD 2002, Bacterial pathogenesis: a molecular approach, 2nd edn, ASM Press, Washington.

STUDENT WORKLOAD REQUIREMENTS

ACTIVITY	HOURS
Examinations	2.00
Lectures	26.00
Private Study	131.00
Tutorials	13.00

ASSESSMENT DETAILS

Description		Marks out of	Wtg(%)	Due date	Notes
INVESTIGATIVE REPORT/S		100.00	70.00	03 Mar 2008	(see note 1)
2HR CLOSED EXAMINATION		100.00	30.00	END S1	(see note 2)

NOTES

1.: Examiner to advise the due date for the Investigative Report. Details of the requirements for the Investigative Report will be provided by the examiner in the Immunopathology 1 Course Handbook 2008.
2.: Examination dates will be available during the Semester. Please refer to the examination timetable when published.

IMPORTANT ASSESSMENT INFORMATION

Attendance requirements:
It is the students' responsibility to attend and participate appropriately in all activities (such as lectures, tutorials, laboratories and practical work) scheduled for them, and to study all material provided to them or required to be accessed by them to maximise their chance of meeting the objectives of the course and to be informed of course-related activities and administration.
Requirements for students to complete each assessment item satisfactorily:
To satisfactorily complete an individual assessment item a student must achieve at least 50% of the marks or a grade of at least C-. (Depending upon the requirements in Statement 4 below, students may not have to satisfactorily complete each assessment item to receive a passing grade in this course.)
Penalties for late submission of required work:
If students submit reports after the due date without prior approval then a penalty of 5% of the total marks gained by the student for the report may apply for each working day late.
Requirements for student to be awarded a passing grade in the course:
To be assured of receiving a passing grade a student must achieve at least 50% of the total weighted marks available for the course.
Method used to combine assessment results to attain final grade:
The final grades for students will be assigned on the basis of the weighted aggregate of the marks obtained for each of the summative assessment items in the course.
Examination information:
In a Closed Examination, candidates are allowed to bring only writing and drawing instruments into the examination.
Examination period when Deferred/Supplementary examinations will be held:
Any Deferred or Supplementary examinations for this course will, unless otherwise arranged with the examiner, be held during the Semester 3 examination period following this offering of the course.
University Regulations:
Students should read USQ Regulations 5.1 Definitions, 5.6. Assessment, and 5.10 Academic Misconduct for further information and to avoid actions which might contravene University Regulations. These regulations can be found at the URL http://www.usq.edu.au/corporateservices/calendar/part5.htm or in the current USQ Handbook.

This version produced 28 Aug 2009.