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BIO2217 Transfusion Science

Semester 2, 2013 External Toowoomba
Units : 1
Faculty or Section : Faculty of Sciences
School or Department : Biological & Physical Sciences
Version produced : 24 April 2014

Contents on this page

Staffing

Examiner: Michael Kotiw
Moderator: Lindsay Brown

Requisites

Pre-requisite: BIO1103 and BIO2108

Rationale

Laboratory professionals working in Transfusion Science require specialised training in this sub-discipline of haematology. The healthcare worker will be need to be able to accurately interpret patient data and perform diagnostic tests with a high level of accuracy and quality control to assist in the control of a range of human diseases. Transfusion scientists also play a role in transplantation tissue harvesting and storage and consequently require a solid working knowledge of blood component fractionation and storage technologies. Awareness of conventional and advanced technologies that will assist in the development of new and improved procedures are integral to the occupation and consequently students require an awareness of recombinant, cell culture, protein analysis and chromatographic technologies that are available . Handling blood and blood components has an inherent increased risk of exposure to blood borne diseases consequently a sound knowledge of safe laboratory practices is essential.

Synopsis

This course builds on the foundations obtained in course BIO2108 Haematology 1. The course provides the theoretical and procedural foundations for performing various blood typing systems. The course also provides a sound foundation of the neonatal and adult diseases in which cross matching and provision of blood and blood components are an essential service. The student is also provided with the theoretical and procedural practices associated with blood fractionation and component storage. The isolation, storage and use of stem cells in transplantation procedures is also explored. The course is designed to enable graduates to commence work in a transfusion laboratory.

Objectives

On completion of this course students will be able to:

  1. describe the pathological implication of tissue ischemia and sustained blood loss;
  2. provide a detailed description of the major blood group systems, the role of blood cell antigens and antibodies;
  3. describe the theory and practice underlying the performance of essential diagnostic procedures such as agglutination tests;
  4. discuss theory and practice of compatibility testing, group, screen and hold and computer cross-matching in the preparation of blood products for transfusion;
  5. be aware of the nature specific pathologies such as: autoimmune haemolytic anaemias; transfusion reactions and haemolytic disease of the newborn;
  6. be able to determine the appropriate use of blood, plasma and blood components Demonstrate an awareness of the nature of various haematological disorders;
  7. discuss the overall management, and in particular the quality control and quality assurance procedures required for the efficient operation of a hospital blood bank;
  8. discuss the theory and application of blood component isolation, fractionation and storage;
  9. discuss the principles underlying stem cell isolation and storage and use in transplantation;
  10. investigate relevant literature and prepare technical reports on aspects of transfusion Science;
  11. become aware of the safety issues associated with working in a diagnostic blood transfusion laboratory.

Topics

Description Weighting(%)
1. A review of the origin, nature, maturity and function of blood cells and blood components 8.00
2. The theoretical basis of blood banking
  • Blood isolation
  • Infectious agent testing
  • Whole blood storage
  • Blood fractionation and component storage
20.00
3. Disorders of haemostasis
  • Thrombocytopaenia
  • thrombocytopathia.
  • Coagulation defects
12.00
4. Microscopic identification of blood cells in blood and bone marrow smears 20.00
5. Blood bank serology
Performance and interpretation Transfusion Laboratory assays:
  • Coagulation tests
  • Blood group testing
  • Compatibility testing
  • Use of anticoagulants
20.00
6. Transplantation
  • Methods for tissue typing including molecular and conventional technologies
  • Isolation, storage and use of stem cella
  • Graft v host disease
12.00
7. Problems with transfusions
  • Transfusion reactions immediate and delayed
  • Associated pathophysiological risks
  • Haemolytic disease of the new born
8.00

Text and materials required to be purchased or accessed

ALL textbooks and materials available to be purchased can be sourced from USQ's Online Bookshop (unless otherwise stated). (https://bookshop.usq.edu.au/bookweb/subject.cgi?year=2013&sem=02&subject1=BIO2217)

Please contact us for alternative purchase options from USQ Bookshop. (https://bookshop.usq.edu.au/contact/)

  • Overfield, J, Dawson, MM, Hamer, D 2008, Transfusion science, 2nd edn, Scion Publishers, Oxfordshire.
    (ISBN 978 1 904842 40 8.)
  • National Health and Medical Research Council (Australia) and Australasian Society of Blood Transfusion, Clinical practice guidelines on the use of blood components: red blood cells, platelets, fresh frozen plasma, cryoprecipitate. ISBN: 9781864961447 2002 P. Free online.

Reference materials

Reference materials are materials that, if accessed by students, may improve their knowledge and understanding of the material in the course and enrich their learning experience.
  • Carr, JH & Rodak, BF 2008, Clinical hematology atlas, 3rd edn, Elsevier Saunders, St Louis, USA.
  • Handin, RI, Lux, SE, Stossel, TP 1995, Blood: Principles and practice of hematology, Lippincott Williams & Wilkins, NY.
    (ISBN: 0397509448.)
  • Kaushansky, K. & Williams, WJ 2010, Williams hematology, 8th edn, McGraw-Hill, NY.
  • Rodak, BF, Fritsma, GA & Doig, K 2012, Hematology: Clinical principles & applications, 4th edn, Elsevier Saunders, St Louis, USA.
  • Stiene-Martin, A. Lotspeich-Steininger, CA & Koepke, JA 1998, Clinical hematology: principles, procedures, correlations, Lippincott, NY.

Student workload requirements

Activity Hours
Examinations 2.00
Online Lectures 26.00
Online Tutorials 13.00
Private Study 131.00

Assessment details

Description Marks out of Wtg (%) Due Date Notes
Assignment 1 20 20 16 Jul 2013 (see note 1)
Assignment 2 20 20 16 Jul 2013 (see note 2)
2HR Closed Examination 60 60 End S2 (see note 3)

NOTES
  1. Examiner to advise the end of semester due date for assignments.
  2. Examiner to advise the end of semester due date for assignments.
  3. Examination dates will be available during the Semester. Please refer to the examination timetable when published.

Important assessment information

  1. Attendance requirements:
    It is the students' responsibility to attend and participate appropriately in all activities (such as lectures, tutorials, laboratories and practical work) scheduled for them, and to study all material provided to them or required to be accessed by them to maximise their chance of meeting the objectives of the course and to be informed of course-related activities and administration.

  2. Requirements for students to complete each assessment item satisfactorily:
    To satisfactorily complete an individual assessment item a student must achieve at least 50% of the marks or a grade of at least C-. (Depending upon the requirements in Statement 4 below, students may not have to satisfactorily complete each assessment item to receive a passing grade in this course).

  3. Penalties for late submission of required work:
    If students submit reports after the due date without prior approval of the examiner then a penalty of 5% of the total marks gained by the student for the report may apply for each working day late late up to ten working days at which time a mark of zero may be recorded. No assignments will be accepted after model answers have been posted.

  4. Requirements for student to be awarded a passing grade in the course:
    To be assured of receiving a passing grade a student must achieve at least 50% of the total weighted marks available for the course.

  5. Method used to combine assessment results to attain final grade:
    The final grades for students will be assigned on the basis of the weighted aggregate of the marks obtained for each of the summative assessment items in the course.

  6. Examination information:
    In a Closed Examination, candidates are allowed to bring only writing and drawing instruments into the examination.

  7. Examination period when Deferred/Supplementary examinations will be held:
    Any Deferred or Supplementary examinations for this course will be held during the next examination period.

  8. University Student Policies:
    Students should read the USQ policies: Definitions, Assessment and Student Academic Misconduct to avoid actions which might contravene University policies and practices. These policies can be found at http://policy.usq.edu.au.

Assessment notes

  1. Harvard (AGPS) is the referencing system required in this course. Students should use Harvard (AGPS) style in their assignments to format details of the information sources they have cited in their work. The Harvard (AGPS) style to be used is defined by the USQ Library's referencing guide. http://www.usq.edu.au/library/referencing

Other requirements

  1. Format: Course lecture and tutorial content will be recorded and provided on Camtasia relay on the basis of 2 lectures and 1 tutorial per week. Tutorials will be primarily used to explore specific syndromes, case studies and or investigative procedures.

    Lectures/tutorials are subject to change if for example, time-tabling falls on public holidays. Examinations will be conducted during the prescribed end of semester examination period.