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BIO3107 Haematology 2

Semester 1, 2013 External Toowoomba
Units : 1
Faculty or Section : Faculty of Sciences
School or Department : Biological & Physical Sciences
Version produced : 25 April 2014

Contents on this page

Staffing

Examiner: Michael Kotiw
Moderator: Lois Higginson

Requisites

Pre-requisite: BIO2108 and BIO2217

Rationale

The aim of this course is to enhance the student's understanding of the science of haematology and to expand in particular on concepts introduced in BIO2108 Haematology 1. This course provides candidates pursuing careers in pathology practice with a focus on haematology a sound knowledge of the nature of haematological disorders including: inherited and acquired haematologic diseases, the range of anaemias; and haematologic malignancies. An overview of blood borne infections is provided to broaden the studentís perspective of the range of disorders. A detailed review and analytical protocols of laboratory methods is provided to ensure that candidates can effectively evaluate laboratory data with a sound understanding of normal reference ranges for such data.

Synopsis

This course builds on the foundations obtained in course BIO2108 Haematology 1. There is a greater focus on the range of haematologic disorders which underpins the ability of the candidate to select appropriate laboratory investigations and analytical procedures. The course provides an advanced level of information relating to haematological diseases and enhances the student's capacity to perform differential diagnosis by providing a sound theoretical basis of investigative methods and analytical methods. In the on-campus mode for this course, lecture content will be delivered on-line, whilst tutorials will be delivered on-campus as a 2 hour session per week.

Objectives

On completion of this course students will be able to:

  1. Describe normal haemoglobin status, blood cell components and haemopoiesis
  2. Describe the nature of mineral and vitamin deficiencies especially with respect to iron deficiency anaemia and iron overload
  3. Describe the nature of diseases associated with bone marrow failure
  4. Describe conditions associated with red blood cell abnormalities including inherited and acquired haemolytic anaemias
  5. Discuss the nature of haematological malignancies including leukaemias, including the classification of lymphomas
  6. Discuss the nature of infectious malignancies
  7. Detail therapeutic procedures associated with:
    abnormal bleeding including anticoagulant and thrombolytic therapy;
    disseminated intravascular coagulation;
    toxicities associated with chemotherapy
  8. Discuss the principles underlying allogenic bone marrow and autologous stem cell transplantation
  9. Discuss the essential of blood component transfusion and associated complications
  10. Understand the theoretical basis of diagnostic tests, including description of blood cell morphology and the nature of reference ranges
  11. Become aware of the principles underlying the use of flow cytometry, human leukocyte antigens, cytogenetics, gene expression principles and coagulation testing
  12. Be able to interpret diagnostic data obtained from haematological tests
  13. Investigate relevant literature and prepare technical reports on aspects of Haematology
  14. Be aware of the safety practices required in a haematology working environment

Topics

Description Weighting(%)
1. Review of Haematopoiesis, haemostasis & coagulation 4.00
2. Haematological disorders associated with mineral and vitamin abnormalities, especially iron level abnormalities 4.00
3. Haematological disorders associated with bone marrow failure 8.00
4. Haematological disorders associated with red blood cells including inherited and acquired haemolytic disorders 12.00
5. Malignant haematologic disorders including leukaemias, myeloproliferative diseases and lymphomas 12.00
6. Overview of blood borne infectious diseases including those associated with HIV, HBV, HCV, EBV, Dengue and malaria, and to be aware of associated infection control issues 8.00
7. Inherited and acquired metabolic blood disorders 12.00
8. Bleeding disorders including platelet, coagulation factor and thrombotic disorders 4.00
9. Therapeutic options associated with coagulation and thrombosis, DIC, and complications associated with chemotherapy 12.00
10. Transplantation of allogenic bone marrow and autologous stem cells 8.00
11. Theory and interpretation of haematological tests including:
blood and bone marrow morphology;
flow cytometry; leukocyte antigens;
cytogenetics, gene expression principles;
coagulation testing and reference ranges.
16.00

Text and materials required to be purchased or accessed

ALL textbooks and materials available to be purchased can be sourced from USQ's Online Bookshop (unless otherwise stated). (https://bookshop.usq.edu.au/bookweb/subject.cgi?year=2013&sem=01&subject1=BIO3107)

Please contact us for alternative purchase options from USQ Bookshop. (https://bookshop.usq.edu.au/contact/)

  • Carr JH & Rodak BF 2009, Clinical Hematology Atlas, 3rd edn, Elsevier Saunders, St Louis, USA.
  • Rodak BF, Fritsma GA & Doig K 2012, Hematology: Clinical Principles & Applications, 4th edn, Elsevier Saunders, St Louis, USA.

Reference materials

Reference materials are materials that, if accessed by students, may improve their knowledge and understanding of the material in the course and enrich their learning experience.
  • Beutler E, Lichtman MA, Coller BS & Seligsohn 2010, Williams Haematology, 8th edn, McGraw-Hill.
  • Cheryl A Lotspeich Steininger, John A Koepke 1992, Clinical Hematology: Principles, Procedures, Correlations, Lippincott Williams & Wilkins.
  • Thomas P Stossel, Samuel E Lux, Robert I Handin 1995, Blood: Principles and Practice of Hematology, Lippincott Williams & Wilkins.

Student workload requirements

Activity Hours
Examinations 2.00
Online Lectures 26.00
Online Tutorials 26.00
Private Study 118.00

Assessment details

Description Marks out of Wtg (%) Due Date Notes
Assignment 40 40 21 Jun 2013 (see note 1)
2HR CLOSED EXAM 60 60 End S1 (see note 2)

NOTES
  1. Examiner to advise the end of semester due date for assignments.
  2. Examination dates will be available during the Semester. Please refer to the examination timetable when published.

Important assessment information

  1. Attendance requirements:
    It is the students' responsibility to attend and participate appropriately in all activities (such as lectures, tutorials, laboratories and practical work) scheduled for them, and to study all material provided to them or required to be accessed by them to maximise their chance of meeting the objectives of the course and to be informed of course-related activities and administration. To maximize their chances of satisfying the objectives of the practical component of the course, students should attend and actively participate in the laboratory sessions in the course. The use of safe procedures in the laboratory will be strictly enforced and continuously monitored to ensure competent performance by students. Students who fail to attend sufficient number of practical sessions (less than 80% of total sessions) may be excluded from completion of the practical course on grounds of safety.

  2. Requirements for students to complete each assessment item satisfactorily:
    To satisfactorily complete an individual assessment item a student must achieve at least 50% of the marks or a grade of at least C-. (Depending upon the requirements in Statement 4 below, students may not have to satisfactorily complete each assessment item to receive a passing grade in this course).

  3. Penalties for late submission of required work:
    If students submit reports after the due date without prior approval of the examiner then a penalty of 5% of the total marks gained by the student for the report may apply for each working day late late up to ten working days at which time a mark of zero may be recorded. No assignments will be accepted after model answers have been posted.

  4. Requirements for student to be awarded a passing grade in the course:
    To be assured of receiving a passing grade a student must achieve at least 50% of the total weighted marks available for the course.

  5. Method used to combine assessment results to attain final grade:
    The final grades for students will be assigned on the basis of the weighted aggregate of the marks obtained for each of the summative assessment items in the course.

  6. Examination information:
    In a Closed Examination, candidates are allowed to bring only writing and drawing instruments into the examination.

  7. Examination period when Deferred/Supplementary examinations will be held:
    No supplementary examinations will be offered in the laboratory component of the course. Any Deferred or Supplementary examinations for this course will be held during the next examination period.

  8. University Student Policies:
    Students should read the USQ policies: Definitions, Assessment and Student Academic Misconduct to avoid actions which might contravene University policies and practices. These policies can be found at http://policy.usq.edu.au.

Assessment notes

  1. In order to attend laboratory classes, students must provide and wear appropriate personal protective equipment. This shall include a laboratory coat, closed-in shoes, and safety glasses. Such equipment must be approved by supervising staff. Failure to provide and wear the appropriate safety equipment will result in students being excluded from classes.

  2. Harvard (AGPS) is the referencing system required in this course. Students should use Harvard (AGPS) style in their assignments to format details of the information sources they have cited in their work. The Harvard (AGPS) style to be used is defined by the USQ Library's referencing guide. http://www.usq.edu.au/library/referencing

Other requirements

  1. STUDENT WORKLOAD REQUIREMENTS
    Format: Course lecture and tutorial content will be recorded and provided on Camtasia relay on the basis of 2 lectures and 1 tutorial per week. Tutorials will be primarily used to explore specific syndromes, case studies and or investigative procedures.

    Lectures/tutorials are subject to change if for example, time-tabling falls on public holidays. Examinations will be conducted during the prescribed end of semester examination period.