You will be introduced in an integrated approach to the cross-disciplinary field of Bioinformatics. This course provides an introduction to both theoretical and practical aspects of DNA and protein sequence analysis including the searching of DNA, protein and nucleic acid databases using homology-based and pattern-based search algorithms, as well as sequence comparisons and alignments and evolutionary analysis. You will develop skills in interfacing with and retrieving information from sequence and genome databases. Methods of sequence alignment including dynamic programming and the supporting statistical theory are introduced. Topics include collection of sequences, sequence alignment, prediction of RNA secondary structure, phylogenetic relationships, gene prediction and protein structure prediction.