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Curriculum Vitae
1. CONTACT INFORMATION
Name: Michael KOTIW
Phone: 07 46 312952
Mobile 04 209 80497
Fax: 07 4631 2952
Email: kotiw@usq.edu.au
2. QUALIFICATIONS
PhD La Trobe University 1987
BSc (Hons) La Trobe University 1981
4. PROFESSIONAL POSITIONS
2006- current Head, Division of Infectious Diseases and Systemic Pathology, Centre for Systems Biology, USQ
2005- current Adjunct Associate Professor in Biomedical Sciences
School of Biomedical Sciences,
University of Queensland
2003- current Associate Professor in Microbiology, USQ
1998- 2005 Director, Centre for Biomedical Research, USQ
1998-2002 Senior Lecturer in Microbiology, USQ
1995-1998 Lecturer in Microbiology
Department of Biological & Physical Sciences
University of Southern Queensland
Toowoomba Queensland 4350
1994 Associate Lecturer in Microbiology
Department of Microbiology,
La Trobe University, Bundoora Vic
1990-1994 Deputy Director of Microbiology
1987-1990 Deputy Head of Microbiology
The Geelong Hospital, Geelong Vic
1986 Scientist Grade 3
1981-1985 Scientist Grade 1
Veterinary Research Institute, Parkville, Vic
5. PROFESSIONAL ACTIVITY
Current
Secretary, Institutional Biosafety Committee (IBC) USQ
Chair, Faculty of Sciences Infection Control Committee, USQ
Member, Faculty of Sciences, Faculty Board USQ
Member, Faculty of Sciences Research and Higher Degrees Committee, USQ
Member, Management Committee, Centre for Systems Biology, USQ
Reviewer, National Medical Research Council, Ministry of Health, Singapore
Reviewer, European Journal of Obstetrics & Gynecology and Reproductive Biology
Reviewer, Rural and Remote Health (Journal of)
Reviewer, The Veterinary Journal
Reviewer, Australian Veterinary Journal
Past
Assessor, Medical Microbiology Laboratories, National Association of Testing Authorities (NATA).
Reviewer, Australian Research Council (ARC)
6. RESEARCH GRANTS AND FUNDING
2007 Uniquest Ltd, University of Queensland, contract research $6,000
Characterisation of TNFα activity in bovine hyperimmune plasma
M Kotiw project 14782
2006 Centre for Systems Biology, internal grant round $15,000
Definition of markers for sepsis in a rat intestinal ischaemia-reperfusion injury intervention model.
M Kotiw and J Lopez
2004 Plasma Ventures Pty Ltd & USQ, collaborative research $60,000
Novel measures for the management of ischaemia/reperfusion injury in the dog
M Kotiw
2003 National Health and Medical Research Council $170,000 NH&MRC Development Project Grant
The use of VLPs expressing Helicobacter pylori epitopes to illicit a protective immune response against the gastric pathogen
M Kotiw, SL Hazell, M F Good and HJ Netter
2001-02 USQ Project Team Research Program (PRTP) $39,352
Cloning and characterising equine procalcitonin, a novel marker for equine bacterial sepsis.
M Kotiw, TK Mukkur, J Dearnaley and N Laws
2001-02 USQ Project Team Research Program $40, 952
A novel recombinant VLP vaccine against Helicobacter pylori.
S Hazell and M Kotiw
1999 Australian Research Council small grant $26,110
An investigation into the heterogeneity of Respiratory Syncytial Virus of human and bovine origin
M Kotiw
1998 Pig Research Development Corporation (PRDC) $167,000
Live attenuated deletion mutants of enterotoxigenic E.coli
as vaccines for colibacillosis in weaned pigs
TKS Mukkur, G Daggard & M Kotiw
1998 Committee for University Teaching & Staff Development
(CUTSD ) $50,000
Flexible delivery: providing different learning
access tracks for registered nurses in rural and remote
areas and internationally in human health sciences.
M Kotiw, S Wilson and D Ross
1998 USQ Project Team Research Program (PTRP) $24,000
Combating the emerging threat of antibiotic resistance:
A search for new drugs from fungi.
R Barrow & M Kotiw
1997 Australian Research Council small grant $12,950
Isolation of a generic molecular marker for the rapid detection of Gram negative septicaemia
M Kotiw
1996 Australian Research Council small grant $18,950
A study into the prevalence, pathogenicity and genotypic
character of Group B streptococci from a cohort of
Aboriginal women and their infants
M Kotiw and G Smallwood
1996-98 USQ Project Team Research Program (PRTP) $45,000
A proposal to use molecular and conventional technologies
To investigate the influence of malnutrition on the increased susceptibility to respiratory infections found in infants of
indigenous origin
M Kotiw, G Smallwood, A Hoey and others
1999 USQ concentration grant $71,000
Delineation of the mechanisms of virulence and immunity to
Pasteurella multocida type A using a mouse pasteurellosis model
TKS Mukkur, M. Kotiw and G Daggard
1994 Australian & New Zealand Intensive Care Society
(ANZICS) $18,000
Detection of Gram negative bacterial sepsis by PCR
CF Corke, M Kotiw and S Ellis
1993 Australian & New Zealand Intensive Care Society
(ANZICS) $18,000
Detection of Gram negative bacterial sepsis by PCR
CF Corke, M Kotiw and S Ellis
7. CONFERENCES PROCEEDINGS
BE Essien, M Kotiw, H Butler and D Strunin (2009)
The effect of canine hyperimmune plasma on TNF-alpha and inflammatory cell levels in a LPS mediated rat air pouch model of inflammation (submitted to Sepsis 2009. Amsterdam, Netherlands November 11-14, 2009)
B Essien, M Kotiw, H Butler, D Strunin and T Roberts (2008)
A mathematical model to account for quantitative iterative effect of TNFα positive feedback mechanisms on inflammatory cascade in TLR-4 mediated TNFα signalling pathway. Proceedings of the 19th International Conference on Genome Informatics (GIW2008) Gold Coast Australia 1-3 December 2008. Poster 28 URL access: http://mlaa.com.au/giw2008/GIW%20Posters.htm
M Kotiw, M Morgan, J Lopez, S M Taylor and IA Shiels (2007)
In vitro and in vivo determination of antiTNFa activity in canine plasma from donors subject to preconditioning with endotoxin. (poster) Sepsis 2007 Paris, France September 2007. Critical Care 2007, 11 (Suppl 4):P23
B Essien, JA Lopez and M Kotiw. (2007)
In-silico identification of novel genomic polymorphisms on the course of sepsis. Bioinformatics Australia 2007 ISBN 978-00-9803047-1-8
M Kotiw, C Olive, M Johnson, M Pandy, S Fry, S L Hazell, H J Netter and M F Good (2006). Exploring the potential for dual vaccination against Hepatitis B virus and Helicobacter pylori using a recombinant virus like particle. (oral paper) Proceedings of the 6th National Congress of the Italian Society for Virology –a joint meeting with the Virus Group of the Society for General Virology (UK). 18-20 September, Orvieto Italy. (UK) Abs97
M Kotiw, IA Shiels, RP Wilson, and L Reeves-Johnson (2006). In vitro effect of hyperimmune sera on TNFa activity. Journal of Veterinary Pharmacology and Therapeutics 29 (Suppl 1) 8: C12
M Kotiw and RP Learmonth (2006) The antimicrobial of activity of glycerol monolaurate (monolaurin) on MRSA and Staphylococcus epidermidis. (poster).
ICNA Conference Brighton UK. 25-27 September 2006
M Kotiw, C Raghaven, M Johnson, I A Shiels and R P Wilson (2006) The effect of equine hyperimmune sera on TNFα activity in a L929 cell bioassay. (oral paper) Proceedings of the Australian Equine Science Symposium 1: 22-23. Gold Coast, Queensland 13-14 June 2006.E1
M Kotiw, GW Zhang, G Daggard, E Reiss-Levy E, JW Tapsall, A Numa and MMA Lahra.
(2004) Breast milk transmission of late onset neonatal group B streptococcal disease. Perinatal Society of Australia and New Zealand. 8th Ann Conf. Sydney 15-18 March.
M Kotiw, GW Zhang, G Daggard and J Tapsall (2003) Analysis of neonatal group B streptococcal disease by RAPD-PCR (oral paper) IBMS Biomedical Science Congress, Birmingham UK September 2003.
M Kotiw, RP Learmonth, D N Shah, H Ross, L Yorkston and JT May (2001)
The bacteriocidal activity of monolaurin on methicillin resistant Staphylococcus aureus (MRSA) (poster). Queensland Health Medical Scientific Meeting, Brisbane December 2001
A Westcott, M Kotiw and R Wilson (2001) The effect of equine hyperimmune plasma on TNFa and LPS activity as determined by cell bioassays. (oral paper), ASM (Queensland Branch), Regional Conference, Toowoomba, December, 2001
R Barrow, SJ Bloor, EJ Grace, SR Kingsland, AP Michael, CD Thompson,
M Kotiw and C Parker (2001) In the footsteps of Florey: utilising cultured microfungi in the search for new antimicrobials World Chemistry Congress Brisbane Australia Abst OF08.
R Barrow and M Kotiw (2000) Antibiotic discovery from cultured Australian microfungi. Poster presentation. Pacifi Chem Congress Honolulu, Hawaii 2000 abst ORGN1313
S Tomasi, M Kotiw, J Boustie & R Barrow (2000) Bioassay guided isolation of potent antibiotic naphthoquinones and derivatives from a cultured coprophilous fungus. Poster presentation. Journees internationales de Pharmacognosie, July 6-7, 2000., Leige Belgium
CD Thompson, RA Barrow & M Kotiw.(2000) Bioactive compounds from cultured entomogenous fungiPoster presentation, RACI Natural Products symposium UNSW Oct 6, 2000 Abst. pge19.
A Michael, M Kotiw & RA Barrow (2000) Drug discovery: Antibiotics active against MRSA from cultured microfungi Oral presentation RACI Natural Products Symposium, UNSW, Oct 6, 2000 Abst p1.
M Kotiw, S Wilson, M Dorman and D Ross (1998) Development of microbiology units suitable for flexible delivery Symposia: The Virtual University: caught in the WEB, ASM Annual Conference, Hobart ,Tas AbsS24.3 pA32
GW Zhang, M Kotiw and G Daggard (1998) Random amplification of polymorphic DNA reveals serotype specific clonal clusters among Group B streptococci. (Poster), ASM Annual Conference, Hobart , Tas Abs GP14 pA101
SA Wilson, M Kotiw, M Dorman and D Ross (1998) Teaching innovations in nursing
education: does provision of multiple learning tracks and delivery modes enhance
student learning in human health. 2nd International Conference in Expanding
Boundaries of Nursing. Mahidol University Thailand. E4
M Kotiw, M Dorman and D Ross (1998) Teaching innovations in nursing education:
Utilising flexible delivery strategies for teaching human anatomy and physiology. 2nd
International Conference in Expanding Boundaries of Nursing. Mahidol University
Thailand. SA Wilson, E4
R Learmonth,M Kotiw and M Sutherland (1997) Biological Methods: A novel course in undergraduate biology. 17th International Conference. in Biochemistry & Molecular Biology, San Francisco Abs E321
CF Corke and M Kotiw. (1994) Detection of Gram negative bacterial sepsis by PCR S Ellis, (Oral paper): Proceed.19th Annual Meeting of ANZICS, Perth p142
CF Corke, M Kotiw, SM Ellis and K Walder. (1993) Detection of bacterial septicaemia by PCR. (Oral paper): Proceed. 18th Annual Meeting of ANZICS, Sydney p94
M Pannacio, MT Withers and M Kotiw (1989) Development of a rapid molecular technique for differentiating Campylobacter spp using a cloned genetic marker. Report: ASM conference Adelaide, Abs 16.1
M Kotiw, Z Nack, CJ Kandiah and HG Williamson. (1989) A longitudinal study of Pseudomonas aeruginosa isolates from a small cohort of patients with cystic fibrosis using BRENDA. (Oral paper): ASM conference, Adelaide, Abs 30.1
C Kandiah, M Kotiw, J Payne, J Low and HG Williamson (1989) A molecular examination of the incidence of MRSA in Geelong Hospital with particular reference to outbreaks in the orthopaedic and ITU units Oral paper: ASM conference Adelaide, Abs 26.3
7. PUBLICATIONS
a. Manuscripts in preparation
M Kotiw, GW Zhang and GE. Daggard. A novel occurrence of specific point mutations in the hylB gene of Group B streptococci results in gene inactivation independent of IS1548
M Kotiw and RP Learmonth. Antimicrobial of activity of glycerol monolaurate on methicillin resistant Staphylococcus aureus and Staphylococcus epidermidis
B Essien and M Kotiw The effect of hyperimmune plasma on inflammatory markers in a LPS mediated rat air pouch model of inflammation
B Essien, M Kotiw, H Butler, D Strunin and A Roberts A mathematical model for the iterative effects of TNFα positive feedback mechanisms on inflammatory cascades in TLR-4 mediated signalling pathways
M. Kotiw, M. Morgan, J. Heath, J. Lopez, S.M. Taylor and I.A. ShielsAnti-TNFα activity in canine plasma from donors preconditioned with an Escherichia coli bacterin
b. Manuscripts under revision
M Kotiw, C Olive, M Johnson, M Pandy, S Fry, SL Hazell, HJ Netter and MF Good. (2009) Recombinant HBsAg Virus Like Particles expressing Helicobacter pylori KatA epitopes confer protection in a murine challenge model. Vaccine (under revision).
c. Papers published
M Kotiw, M Morgan, SM. Taylor and IA Shiels (2009) Detection of anti-tumor necrosis factor-a (TNFa) activity in canine hyperimmune serum using a TNFa inhibition assay. Veterinary Clinical Pathology (in press) DOI:10.1111/j.1939-165X.2009.00166
RA Davis, V. Andjic, M. Kotiw and RG Shivas (2005) Phomoxin B and C, new polyketides from a terrestrial fungus of the genus Eupenicillium. Phytochemistry 66:2771-2775.
RA Davis and M Kotiw (2005) Synthesis of the fungal natural product (-)-xylariamide A. Tetrahedron Letters 46:5199-5201.
PC Healy, J K Mitchell, A Hocking, N Tran-Dinh, JI Pitt, RG Shivas, M Kotiw and RA Davis (2004) Xanthones from a microfungus of the genus Xylaria. Phytochemistry 65:2373-2378
M. Kotiw , G.W. Zhang, G Daggard, E.A. Reiss-Levy, J.W. Tapsall and A. Numa (2003) Late-Onset and recurrent neonatal group B streptococcal disease associated with breast milk transmission. Pediatric and Developmental Pathology 6:251-256.
AP Michael, EJ Grace, M Kotiw & R A Barrow (2003) Isochromophilone IX, A Novel GABA Containing Metabolite Isolated from a Cultured Fungus, Penicillium sp. Aust. J. Chem. 56:13-15.
AP, Michael, EJ. Grace, M. Kotiw & RA. Barrow. Ravenic Acid (2002) A New Tetramic Acid Isolated from a Cultured Microfungus, Penicillium sp. J. Nat. Prod.
65:1360-1362
G.W. Zhang, M. Kotiw and G Daggard. (2002) A RAPD-PCR genotyping assay which correlates with serotypes of Group B streptococci. Letters in Applied Microbiology 35:247-250
M Kotiw, R Learmonth & M Sutherland. (1999) Biological methods: a novel course in undergraduate biology Biochemical Education 27: 131-134
G Smallwood, C White and M Kotiw (1997) The relevance of human rights to health status in Australian Aboriginal and Torres Strait Islander Communities Health and Human Rights 2(2): 127-136
M Kotiw and G Smallwood (1996) Infectious diseases in Australia Australasian Science 17: 11-14
S Ellis, M Kotiw and S Garland (1996) Restriction endonuclease analysis of Group B streptococcal isolates from two distinct geographical regions. J Hospital Inf 33:279-287
M Kotiw, CR Wilks and JT May (1995) The effect of serial in vivo passage on virulence and stability of DNA restriction profiles of an infectious laryngotracheitis virus of low virulence Vet.Microbiol 45: 71-80
WJ Dimech, AG Hellyar, M Kotiw, D Marcon and S Ellis (1993)Typing of a single source outbreak of Pseudomonas picketti J Clin Micro 31: 3001-3006
AW Lepper, CR Wilks, M Kotiw, JT Whitehead, and KS Swart (1989) Sequential bacteriological investigations in relation to cell mediated and humeral antibody responses of cattle infected with Mycobacterium paratuberculosis and maintained on normal or high iron intake. Aust Vet J 66(2): 50-55
M Kotiw, M Sheppard, JT May and CR Wilks. (1986) Differentiation between virulent and avirulent strains of infectious laryngotracheitis virus by DNA-DNA hybridisation using a cloned DNA marker. Vet Microbiol 11: 319-330
M Kotiw, CR Wilks, M Sheppard, and JT May (1984) Comparison of methods for the isolation and purification of ILTV DNA. Vet Microbiol, 9: 415-419
JA Hancock, CR Wilks, M Kotiw and JD Allen. (1984) The long term efficacy of Hardjo-Pomona vaccine in preventing leptospiuria in cattle exposed to natural challenge with Leptospira interrogans serovar hardjo. Aust Vet J. 61:54-56
M Kotiw, CR Wilks and JT May. (1982) Differentiation of infectious laryngotracheitis virus strains using restriction endonucleases. Avian Dis, 26:718-731
RL Reece, D Grix and M Kotiw. (1981) The distribution of naturally acquired antibodies against infectious bursal disease virus in Victoria. Aust Vet J 57:201
CR Wilks and M Kotiw (1979) Isolation of ILTV from tracheas. Aust Vet J, 55:553
8. SABATTICALS
2008 Centre for Respiratory Research
Rayne Institute, University of London,
University College of London
London UK
2008 School for Biomedical Sciences
University of Queensland
St Lucia Queensland
2000 Albert Sakzewski Virus Research Centre (SASVRC),
Royal Children’s Hospital & Health Service District
Herston, Brisbane QLD
9. REFEREES
Professor Stuart Hazell
Past Dean , Faculty of Sciences, University of Southern Queensland
Ph 0413051601
Professor Karim Miran-Khan
Professor in Clinical Sports Medicine
University of British Columbia
Vancouver, Canada
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