Osteoarthritis (OA) is the most common form of arthritis. Topical non steroidal anti-inflammatory drugs (NSAIDs) and oral paracetamol (APAP) are frequently used as individual agents for managing OA pain. However, limited data is available for the effectiveness of combination treatment. A key premise of this study is a logical extension that the pharmacological effect of analgesics via APAP & anti-inflammatory via NSAID meets the treatment needs of pain and inflammation associated with OA. This study seeks to address the lack of investigations into evidence-based APAP and topical diclofenac combination treatment for OA pain, using statistical techniques and inferential methods enabled by modeling and simulation techniques to inform an evidence-based practice perspective & recommendations on regimen use for safe &effective pain relief for chronic OA sufferers.
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